Are the results applicable to my patients?
Were the clinically important
outcomes reported?
Were absolute risk data reported
for dichotomous outcomes ?
Are the overall results
clinically significant?
Would these patients?
Did the treatment cause harm
which might outweigh the benefit for my patient(s)?
If this study is does not answer the original question or if the answer is not meaningful after the above appraisal, then toss out the study and proceed to the next one.
If the answer to the above overall question is YES, then write a C.A.T. so the rest of us don't need to look this up again for a while.