Are the results applicable to my patients?
Was the study population sufficiently similar to my own?
Do the results help to identify which of my patients will most benefit from specific therapies?
Do the results allow me to tell my patients what they want to know?
If this study is does not answer the original question or if the answer is not meaningful after the above appraisal, then toss out the study and proceed to the next one.
If the answer to the above overall question is YES, then write a C.A.T. so the rest of us don't need to look this up again for a while.
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